![]() ![]() 235000013305 food Nutrition 0.000 title claims abstract description 10.235000019219 chocolate Nutrition 0.000 title claims abstract description 8.240000000280 Theobroma cacao Species 0.000 claims abstract description 21.235000009470 Theobroma cacao Nutrition 0.Since 2003, Silicium has been manufacturing the authentic formula of Doctor of Science Loïc Le Ribault, pioneer and creator of liquid organic silica, a product protected by patent."Composition for therapeutic use comprising organic silicon compounds" priority patent number FR8519204A, and European EP0228978A1 and EP0228978B1, and in the USA with patent US5391546. presentarn modificaciones en sus propiedades organolpticas y pH. Since 2011 SILICIUM LABORATORIES, by the will of Dr Loïc Le Ribault is the owner of this intellectual property, its patents and trademarks. Therefore, it is the only company authorized to use 'organic silica of Loïc Le Ribault', different and more advanced than Norbert Duffaut's. El silicio orgánico lo podemos considerar un elemento funcional, con múltiples aplicaciones en diversos campos de la salud. ![]() Since then, Silicium continues to lead dozens of studies and actions to improve the quality of its products. ![]() Our Barcelona-based laboratory has facilities authorised to manufacture medicines for the EU under European Medicines Agency (EMA) regulations and Good Manufacturing Practice (GMP). Our products are manufactured according to pharmaceutical-grade standards, even stricter than those of a food or dietary supplement plant.Ī few years ago, we demonstrated in other studies in patients with bone and joint problems the effect of silica in reducing joint pain, improving quality of life and improving mobility. All rights reserved.Our preclinical studies in cells have shown that silica in bone precursor cells increases collagen synthesis and promotes its mineralization. Further research as in the obtaining of such derivatives via synthesis and their in vivo testing to confirm their higher pharmacological potential is currently on the way.ĪDME/Tox Anti-allergic Anti-inflammatory/Antinociceptive Antidepressant Anxiolytic N-methylanthranilic acid esters.Ĭopyright © 2019 Elsevier Ltd. Overall the second modification (5-pentanoic acid, 5-pentanoic acid and 5-(2-anilino)pentanoic acid) of all three original molecules was the one that achieved highest score in molecular docking and a better combination of the other parameters. Derivatives of the three original molecules were proposed. Interestingly this compound presented the best in vivo profile in previous studies by the group. The compound IMA seems to be the best one when all the combined parameters are put together. This manuscript dealt with their assessment in six pharmacological targets to understanding anti-inflammatory, antinociceptive, anxiolytic, antidepressant and anti-allergic activities using docking molecular as well as their pharmacokinetics and toxicological parameters prediction. The in silico evaluation for the three previously synthesized compounds (Methyl (MMA), propyl (PMA) and isopropyl (IMA) N-methylanthranilate), MMA and IMA originally found in the leaf essential oil of Choisya ternata, provided a very good confirmation for the in vivo pharmacological results obtained with such compounds for a number of pharmacological targets. ![]()
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